VIRuses: EMergence, Interactions and Evolution
Research themes
The team’s work targets various animal and/or zoonotic respiratory viruses. Its research themes include both surveillance projects and projects aimed at understanding the mechanisms of infection or co-infection of poultry and cattle, with the emphasis on studying the associated host response.
The aim is to contribute to our understanding of virus-host interactions, viral emergence and, more generally, the evolution of viruses of interest.
Various approaches and methods are used in these projects to understand viral evolution and characterize interactions between viruses and hosts, and even between co-infecting pathogens.
Our main axes are:
- EVOLUTION: AIV LP to HP, from animal to zoonosis, impact of vaccination
- EMERGENCE: surveillance of avian and bovine respiratory viruses
- PATHOGENESIS and TRANSMISSION (avian/cattle/human hosts, in vitro-ex vivo-in vivo)
People
- Mariette DUCATEZ (DR1, team leader)
- Christelle CAMUS (PR2, co-leader)
- Maxence DELVERDIER (PRex)
- Maxime FUSADE-BOYER (MC)
- Gilles MEYER (PRex)
- Romain VOLMER (PR2)
- Marie DARD (agent cont. – 50%) – mutual. VIRAL
- Charlotte FORET-LUCAS (IE – 80%) – mutual. VIRAL
- Aurélie SECULA (TREX – 10%) – mutual. VIRAL
- Anne-Laure DUKUNDE (ATP) – mutual. IHAP
- Fatima-Zohra SIKHT (post-doc)
PhD students, residents and Master students
- Marie CORBIN
- Juliette GROSS
- Aldair MARTINEZ-PINEDA
- Maverick MONIE-IBANES
- Bertille POUGET
- Margot SARRAT
- Alexandre RIBEIRO
5 main publications
Dupré G & Volmer R, Influence of viral genome properties on polymerase fidelity. Trends in Genetics 2023
Foret-Lucas C, Figueroa T, Coggon A, Houffschmitt A, Dupré G, Fusade-Boyer M, Guérin JL, Delverdier M, Bessière P, Volmer R., In Vitro and In Vivo Characterization of H5N8 High-Pathogenicity Avian Influenza Virus Neurotropism in Ducks and Chickens. Microbiol Spectr. 2023
Gaudino M., Lion A., Sagné E., Nagamine B., Oliva J., Terrier O., Errazuriz-Cerda E., Scribe A., Sikht F.Z., Simon E., Foret-Lucas C., Gausserès B., Lion J., Moreno A., Dordet-Frisoni E., Baranowski E., Volmer R., Ducatez M.F., Meyer G., The activation of the RIG-I/MDA5 signalling pathway upon Influenza D virus infection impairs the pulmonary pro-inflammatory response triggered by Mycoplasma bovis superinfection. Journal of Virology. 2023; e0142322.
Gaudino M, Valarcher JF, Hägglund S, Näslund K, Zohari S, Ducatez MF, Meyer G. Molecular and genetic characterization of bovine parainfluenza type 3 European and Vaccine strains. Infect Genet Evol. 2023
Xie R, Edwards KM, Wille M, Wei X, Wong SS, Zanin M, El-Shesheny R, Ducatez M, Poon LLM, Kayali G, Webby RJ & Dhanasekaran V, The episodic resurgence of highly pathogenic avian influenza H5 virus. Nature. 2023