Immunology and Alternative to Antibiotics
Research themes
The IALTA section studies the mechanisms of immunity in response to infection, in link with the host’s genetic background. The team investigates methods of increasing the ruminant immune protection against common infectious diseases, in particular by training its innate compartment and reinforcing physical defenses at the contact barriers with pathogens. The work is applied to the predominant diseases of the studied species (bovine, ovine, caprine), whether mammary or respiratory infections.
Three axes are developed:
- Immune training through vaccination and immune-stimulation with a variety of compounds
- Physiopathology of inborn errors of immunity in ruminants
- Immune and inflammatory characterization through omics technologies (scRNA-seq, lipidomics, multiplex immunoassays, flow cytometry)
People
- Gilles FOUCRAS (PReX, Team leader)
- Laurence GUZYLACK (CRHC, Coleader)
- Philippe GUERRE (PR1)
- Alix PIERRON (AERC)
- Guillaume TABOURET (CRCN)
- Blandine GAUSSERES (IECN)
- Christian TASCA (TReX – 60%)
PhD students
- Lucie DUTHEIL
- Elodie LASSALLETTE (CIFRE)
5 main publications
Pierron A, Guzylack-Piriou L, Tardieu D, Foucras G, Guerre P. Zymosan-induced murine peritonitis is associated with an increased de novo sphingolipid synthesis without changing the long to very long chain ceramide ratio. Int. J. Mol. Sci. 2023; 24(3):2773.
Walachowski S, Breyne K, Secher T, Cougoule C, Guzylack L, Meyer E, Foucras G, and Tabouret G. Oral supplementation with yeast β-glucans improves the resolution of Escherichia coli-associated inflammatory responses independently of monocyte/macrophage immune training. Front Immunol2022;13:1086413.
Lesueur J, Walachowski S, Barbey S, Cebron N, Lefebvre R, Launay F, Boichard D, Germon P, Corbiere F and Foucras G. Standardized whole blood assay and bead-based cytokine profiling reveal commonalities and diversity of the response to bacteria and TLR ligands in cattle. Front Immunol 2022;13:871780.
Hassel C, Gausseres B, Guzylack L, and Foucras G. Ductal macrophages predominate in the immune landscape of the lactating mammary gland. Front Immunol 2021;12:754661.
Cebron N, Maman S, Gausserès B, Walachowski S, Rainard P, Foucras G. Th17-related mammary immunity, but not a high systemic Th1 immune response is associated with protection against E. coli mastitis. npj Vaccines 2020 ;5(1):108.